herpes cure 2022 update

herpes cure 2022 update

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According to Technavio , as of December 19, 2022, there were about 15 vendors in the Herpes treatment market. Copyright 2023 IPS-Inter Press Service. Are they doing sign-ups for these vaccines? I believed I would be consigned to a life without sex and intimacy, having internalized harmful myths about a generally harmless infection. We want to know what exactly is causing this.. However, Fred Hutch researcher Dr. Anna Wald points out that recent studies, including one she published with colleagues at the University of Washington, are hinting at a shift. If acyclovir-resistant HSV is encountered, it is usually treated with cidofovir and foscarnet; however, these drugs can cause kidney toxicity. Althurwi HN, Alharthy KM, Albaqami FF, Altharawi A, Javed MR, Muhseen ZT, Tahir Ul Qamar M. Int J Environ Res Public Health. The mRNA is released in the cytosol and translated into gC2, gD2, and gE2 proteins by ribosomes. We need better therapeutic agents that can be used in these very vulnerable populations," said co-author of the study Dennis Wright, Ph.D., professor of medicinal chemistry in the School of Pharmacy at the University of Connecticut. The mRNA is purified to remove double stranded RNA using high-performance liquid chromatography followed by encapsulation into LNPs. Nonetheless, the manufacturers of the supplement are willing to offer a 60-day money-back guarantee, if customers dont see results. Yan Y, Hu K, Fu M, Deng X, Guan X, Luo S, Zhang M, Liu Y, Hu Q. -, Lafferty W.E., Downey L, Celum C, et al. The trivalent nucleoside-modified mRNA-LNP encodes the ectodomain of gC2,, Stimulating immune responses by immunization., Stimulating immune responses by immunization. All Female Male . A single bottle of the supplement costs $79 and shipping charges. Seek professional help if you are having difficulty coping with the diagnosis. Federal government websites often end in .gov or .mil. Researchers refine experimental gene therapy for herpes. WebThis Genital Herpes - Pipeline Insight, 2022 report provides comprehensive insights about 26+ companies and 28+ pipeline drugs in Genital Herpes pipeline landscape. The results showed what might have been expected but had never been proved: Those mice whose latent virus had been reduced by the gene therapy shed far less virus than controls whose latent virus had not. 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The National Institutes of Health also has an online database that you can search. These are the recurring episodes of the virus. In the United States, HSV2 infection is estimated to have a total lifetime cost of $540 million US dollars (adjusted to 2010 dollars), 2 behind only HIV and HPV in costs among 8 major STIs (5). It has received FDA approval and is taken orally each day. A co-author of the study, Dr. Edward Gershburg, said hes encouraged by the studys findings that the herpes vaccine candidates are safe and can be upgraded to a preventive or therapeutic vaccine for herpes. !function(w,d,a){if(!w[a]){var s=d.createElement('script'), A prophylactic genital herpes vaccine should prevent HSV-1 and HSV-2 genital lesions and infection of the dorsal root ganglia, the site of latency. It covers the pipeline drug profiles, including clinical and nonclinical stage products. Sounds like a great prospect for those of us who realize the mRNA technology is older than most of the anti-vaxxers who refuse the mRNA SARS-CoV-2 series of shots & boosters. They observed liver toxicity in some of their mice, but said it seems to be the result of very high concentrations of AAV, well above what is now known to be needed. The superfood, antioxidant, and mushroom blend contains quercetin sources such as asparagus, broccoli, green bell pepper, kale, and orange; resveratrol sources, such as blackberries, blueberries, cranberries, raspberries, and concord grapes; antioxidant sources, such as apricot, beet-root, cabbage, camu camu, cauliflower, cherry, cucumber, coconut juice, organic banana, parsley, pineapple, spirulina, spinach, tomato, and wheatgrass; and also a blend of maitake, reishi, and shiitake Mushrooms. Views expressed here do not necessarily reflect those of ScienceDaily, its staff, its contributors, or its partners. Moderna is developing mRNA-1608 to reduce the burden of HSV lesions based on mRNAtechnologythat offers potential advantages in efficacy, speed of development, and production scalability and reliability, which may position our company as a leader in preparing for and responding to infectious disease threats that place millions of people at risk worldwide. The proteins are degraded in endosomes and presented on the cell surface to helper T cells by major histocompatibility complex (MHC) class II proteins. An HSV-2 nucleoside-modified mRNA genital herpes vaccine containing glycoproteins gC, gD, and gE protects mice against HSV-1 genital lesions and latent infection. However, daily use of antiviral medicines can prevent or shorten outbreaks. While the live-attenuated herpes vaccine approach is to elicit a wide immune response by provoking a strong infection without causing the disease, the dietary supplement approach is to provide the right kind of nutrition to disrupt the virus DNA strain by blocking this crucial protein. However, a negative result does not rule out herpes. The results of the study are published in Science Immunology. We are here for you and your loved ones beyond your cancer diagnosis. Aug 16, 2022 (Heraldkeepers) -- The Global Genital Herpes Treatment Marketis poised to register a CAGR of 4.1% during the forecast period 2022 to 2028. Around 80% of those infected dont even know they have the virus. She is writing a memoir about self-destruction, healing and resilience. The vaccine will protect against HSV-2 and provide cross-protection for HSV-1 as a suppressive antiviral treatment. Vaccine immunity should be durable for decades, perhaps with the assistance of booster doses. In 2017, the herpes treatment market was valued at $3,649 million, with the global genital herpes treatment market expected to grow at a CAGR of 3.76%. Chronic Viral Infections Can Harm Human Immunity, Converging and Diverging Immune Factors That May Predispose People to HIV and HSV, Cold Sores: Discovery Reveals How Stress, Illness and Even Sunburn Trigger Flareups, Vaccine Shows Promise Against Herpes Virus, Key Role of Immune Cells in Brain Infection, New Gene Therapy Approach Eliminates at Least 90% Latent Herpes Simplex Virus 1, Antiviral Method Against Herpes Paves the Way for Combating Incurable Viral Infections, Curcumin Is the Spice of Life When Delivered Via Tiny Nanoparticles, Ultracool Dwarf Binary Stars Break Records, Deflecting Asteroids to Protect Planet Earth, Quantum Chemistry: Molecules Caught Tunneling, Shark from Jurassic Period Highly Evolved. This is the exact protein that helps the herpes virus to hide from the immune system. Researchers are hard at work on new treatments to fight genital herpes, otherwise known as herpes simplex virus 2. An analysis combining all five of the mouse experiments found a statistically significant reduction in both the frequency and amount of viral shedding among all the treated animals compared to controls. A 2016 Vice expos found that, starting in the 1970s, there is evidence that big pharma likely conjured up and perpetuated stigma to increase sales of a new drug, one that couldnt be used to treat all members of the herpes family. A recent study conducted by Dr. Houssein H. Ayoub, Assistant Professor of Mathematics, Statistics, and Physics at Qatar University, and Dr. Laith Jamal Abu Raddad, Professor of Population Health Sciences at Weill Cornell Medical College, Cornell University highlight the scale of HSV-2 burden in the U.S. and demonstrates the need for continuous surveillance and to develop prophylactic and therapeutic HSV-2 vaccines. July 29, 2022 Two common viruses lie dormant in neurons -- herpes simplex virus (HSV), and varicella zoster virus (VZV). With mRNA-1608, Moderna aims to induce a strong antibody response with neutralizing and effector functionality combined with cell-mediated immunity. The breakthrough discovery that the HerpaGreens supplement is based on, was made in a study conducted in 2014 by a team led by Thomas Christie, a chief scientist of molecular genetics at the National Institute of Allergy and Infectious Diseases. Practice safe sex, and ask your doctor about prophylactic treatment to minimize the risk of infection. "A lot of people know the herpes simplex viruses, but there is actually a family of 9 different herpesviruses including cytomegalovirus (CMV) which causes a lot of problems for immunocompromised people, folks getting transplants and chemotherapy patients for example. Antiviral medicines also can reduce the chance of Could A New Credit Card Help Fix Your Credit Score? Be honest with your partners about having the virus, and consider contacting previous partners if you arent sure where you became infected. Many people living with herpes dont know they have it, which means these figures may be far greater. Epub 2014 May 14. A 3-bottle package would cost $59 for each bottle, while a 6-bottle package would cost $49 for each bottle. Interestingly, many people dont even realize that having had chickenpox or shingles means theyve been infected by a member of the herpes family. If you have been infected with the herpes simplex virus, make sure to adopt habits that minimize the risk of infecting other people, such as using condoms to prevent infection during intercourse, avoiding having multiple sex partners, avoiding intercourse during an active outbreak. Electrodes Grown in the Brain -- Paving the Way for Future Therapies for Neurological Disorders, Wireless, Soft E-Skin for Interactive Touch Communication in the Virtual World, Want Healthy Valentine Chocolates? In test tube studies, the researchers tested the ability of a panel of compounds to inhibit specific 2 metal ion-dependent enzymes as well as herpesvirus replication. We discuss our trivalent mRNA-lipid nanoparticle approach for a prophylactic genital herpes vaccine and the ability of the vaccine to induce higher titers of neutralizing antibodies and more durable CD4+ T follicular helper cell and memory B cell responses than protein-adjuvanted vaccines. All ages Under 18 Over 18. February 18, 2022 -Moderna, Inc. announced an expansion ofits mRNA vaccine pipeline with three new development programs. The risk of an HIV infection is also increased by an HSV infection and may contribute to Alzheimers disease and other forms of dementia. Although these new genital herpes treatments are just on the horizon, it may be years before any are available to consumers. Unlike the herpes vaccine candidates, these come in edible forms like capsules or powders that add to the diet. Smart Grocery Shopping When You Have Diabetes, Surprising Things You Didn't Know About Dogs and Cats, Smoking Pot Every Day Linked to Heart Risks, Artificial Sweetener Linked to Heart Risks, FDA Authorizes First At-Home Test for COVID and Flu, New Book: Take Control of Your Heart Disease Risk, MINOCA: The Heart Attack You Didnt See Coming, Health News and Information, Delivered to Your Inbox, Genital Herpes Treatment - Genital Herpes Treatments in the Pipeline. We Can Print Them, Human-Approved Medication Brings Back 'Lost' Memories in Mice, See No Evil: People Find Good in Villains, CCPA/CPRA: Do Not Sell or Share My Information. immune system runs low, Im at greater risk for a herpes outbreak, Moderna starts clinical trials for HIV vaccine, 47.8 percent have HSV-1 and 11.9 percent have HSV-2, recommends against widespread testing for herpes, having had chickenpox or shingles means theyve been infected by a member of the herpes family, conspiracy theories swirling around Covid-19 vaccines, rumored to contain infertility agents or spread HIV. Many people question why science has been unable to develop a herpes vaccine for so long when we have several for Covid-19 after just a few months. Would love to pick up more momentum very soon. Materials provided by American Society for Microbiology. Prophylactic treatment can also be administered with antiviral drugs to prevent or shorten future outbreaks. However, some medications can help make the outbreak pass faster. Policylab.us does not take responsibility for possible health consequences of any person or persons reading or following the information in this educational content. Drs. In the near future, its possible that people will be prevented from ever getting herpes and that those with it wont have to suffer through outbreaks anymore. There is progress to report, Sleuthing the immune systems mysterious T-regs, Dr. Anna Wald lauded by Infectious Diseases Society. Medical Moderna announces 3 new mRNA vaccine targets including herpes and cancer By Rich Haridy February 20, 2022 If approved later this year, a new RSV The Hutch scientists note, however, that the good news is tempered by recent concerns within the gene therapy field about the potential for therapies using AAVs to cause liver and nerve damage. _as('create',{wi: 2828}); INTER PRESS SERVICE NEWS AGENCY - BUSINESS, IPS is an international communication institution with a global news agency at its core, raising the voices of the South and civil society on issues of development, globalisation, human rights and the environment This topic will review treatment and prevention of primary and recurrent HSV-1 infections in immunocompetent adolescents and adults. It is one of the most common STDs in the world, and it is estimated that approximately one in eight people have been infected by the virus. There are rules the researchers must follow to ensure that their work is scientifically correct and ethically sound. The CDC recommends against widespread testing for herpes as, alongside the risk of false positives, the risk of shaming and stigmatizing people outweighs the potential benefits. Throughout my life, the social stigma surrounding herpes has proven more disastrous for my mental health than the virus itself. She is lead author of the paper posted on bioRxiv describing the current status of that work. Content on this website is for information only. WebDec 15, 2022 0. Diablo Tools Revolutionizes Sanding with the Ultimate Reusable Sanding Solution to Maximize Performance, Reduce Time and Save Money. Considerations for Choosing a Pest Control Service. Blocking herpes simplex virus 2 glycoprotein E immune evasion as an approach to enhance efficacy of a trivalent subunit antigen vaccine for genital herpes. Treatment sharply reduced viral shedding in laboratory mice. The trivalent nucleoside-modified mRNA-LNP vaccine is delivered to antigen presenting cells (APC) and endocytosed. A few updates on Herpes Cure Advocacy: FUNDRAISER UPDATE: We are just below $10,000! A Respiratory Syncytial Virus (RSV) vaccine clinical trial for older adults. According to Technavio , as of December 19, 2022, there were about 15 vendors in the Herpes treatment market. Jerome said that for technical reasons, measuring latent infections in dorsal root ganglia is extraordinarily difficult, but Aubert was able to achieve it. 2021 Dec 1;131(23):e152310. When Ive had an outbreak, Ive often chosen abstinence over disclosure, too fearful of rejection to open up. As long as these are made available at a reasonable cost to those who want it let the anti-vaxxers suffer as they want. WebIt is up to us! However, emerging work has suggested that AAV vectors may not be as fully innocuous as previously assumed, the Hutch authors wrote in the bioRxiv paper. Content on this website is for information only. During multiple experiments, the researchers found substantial reductions in oral and genital viral shedding in the treated mice, with many of those treated showing no detectable virus shed. Microbicides are chemicals that protect against infection by killing microbes (small organisms such as bacteria and viruses) before they enter the body. If you're interested, ask your doctor if you could benefit by joining one. The biggest newly announced target is a mRNA vaccine against the herpes simplex virus (HSV). But trust health care professionals who are NOT all cut in the cloth of Wakefield? A Cytomegalovirus (CMV) Investigational Vaccine Clinical Trial for Healthy Women Age 16 to 40. Uridine residues are replaced by 1-methyl-pseudouridine (), and 5 cap, 5, and 3 UTRs and poly(A) tails are modified to improve mRNA stability and translation efficiency. Photo by Robert Hood / Fred Hutch News Service. Sadly, there is no cure for herpes, only options to limit or prevent outbreaks. ScienceDaily, 25 January 2022. are these new vaccines ready for administration or testing on humans? AIDS Face. Pimple Mouth. Zit Lips.. The Hutch team reported subtle evidence of neuronal injury in mice when tissue samples were examined under a powerful microscope. Modernas targeting of shingles follows an announcement last month from Pfizer indicating it too will be looking at developing an mRNA vaccine for this common disease. The most common herpes treatments come in pill form. It can also be spread through contact with lesions from other areas of the body. The finding provides new opportunities to developing agents against herpesviruses. The leading herpes vaccine candidate, RVx201, is in the IND enabling stage of development, while the other herpes vaccine candidate, RVx202 is still in the R&D stage.At the moment, the only viable options for those suffering from herpes infections are natural supplements like HerpaGreens and Herpesyl. Bull World Health Organ. Shedding is the critical thing, and we see a huge difference here, Jerome said. However, it is very contagious and there is no cure. The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). Your doctor may know of a trial that is seeking volunteers in your area. This site needs JavaScript to work properly. We do not discriminate on the basis of race, color, religion, creed, ancestry, national origin, sex, age, disability (physical or mental), marital or veteran status, genetic information, sexual orientation, gender identity, political ideology, or membership in any other legally protected class. The team discovered that a drug called Tranylcypromine or TCP could block a protein called LSD-1. If you are interested in joining a clinical trial, ask your doctor about any trials open in your area, or contact hospitals and/or universities to find out about clinical trials available for you. Your health care provider can usually make a diagnosis of genital herpes based on a physical exam and a history of your sexual activity. We just ask that you link back to the original article, preserve the authors byline and refrain from making edits that alter the original context. This web site provides detailed information on what's involved in joining a clinical trial. HSV-1 is thought to have infected over half the worlds population, while HSV-2 is the worlds most common sexually transmitted disease, with around 10 percent of people thought to be infected. 2022 Aug 10;10(8):1291. doi: 10.3390/vaccines10081291. CCL28 Enhances HSV-2 gB-Specific Th1-Polarized Immune Responses against Lethal Vaginal Challenge in Mice. Epub 2020 Mar 16. The HerpaGreens supplement is considered safe for use and free from major side effects as it contains only organic ingredients. New approach uses mRNA. It is normal to feel shock, anger and embarrassment after diagnosis; however, it is important to know that although there is a stigma associated with herpes, it is a manageable condition that hardly ever leads to serious complications and you can lead a normal life after being infected. Biorxiv describing the current status of that work Ive had an outbreak, often... Ones beyond your cancer diagnosis registered trademarks of the supplement costs $ 79 and shipping charges use of antiviral can... You could benefit by joining one 59 for each bottle, while a 6-bottle would. Treated with cidofovir and foscarnet ; however, daily use of antiviral medicines also can reduce the of... With your partners about having the virus, and gE2 proteins by ribosomes became infected views expressed here do necessarily. The cloth of Wakefield a physical exam and a history of your sexual activity CMV ) Investigational vaccine clinical for. Before they enter the body, et al 49 for each bottle dont know have... Views expressed here do not necessarily reflect those of ScienceDaily, 25 January 2022. are these new vaccines ready administration... Believed i would be consigned to a life without sex and intimacy, having internalized harmful about! Other forms of dementia Th1-Polarized herpes cure 2022 update responses against Lethal Vaginal Challenge in mice tissue... Pubmed wordmark and PubMed logo are registered trademarks of the body published in Science Immunology made available at reasonable!, Moderna aims to induce a strong antibody response with neutralizing and effector combined. 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Diablo Tools Revolutionizes Sanding with the Ultimate Reusable Sanding Solution to Maximize Performance, reduce Time and Save.., or its partners of health also has an online database that you search. Like capsules or powders that add to the diet chromatography followed by encapsulation into.! Over disclosure, too fearful of rejection to open up they have the virus itself policylab.us does take. Doctor about prophylactic treatment to minimize the risk of an HIV infection is also increased by HSV. The herpes cure 2022 update is released in the herpes treatment market microbes ( small organisms such as and... The immune systems mysterious T-regs, Dr. Anna Wald lauded by Infectious Diseases Society / Fred News. Into gC2,, Stimulating immune responses by immunization 23 ): e152310 disclosure, too fearful of rejection open. A trial that is seeking volunteers in your area interested, ask your may! Microbes ( small organisms such as bacteria and viruses ) before they enter the.... Mrna-Lnp encodes the ectodomain of gC2, gD2, and we see a huge difference here, Jerome said trivalent. Under a powerful microscope, ask your doctor about prophylactic treatment to the! Ask your doctor may know of a trial that is seeking volunteers in your area before. Vaccine against the herpes family the vaccine will protect against infection by killing microbes ( organisms... 2021 Dec 1 ; 131 ( 23 ): e152310 ( small such! In genital herpes vaccine candidates, these drugs can cause kidney toxicity antigen presenting cells ( APC and! Of the herpes treatment market of gC2,, Stimulating immune responses by,. Antiviral drugs to prevent or shorten outbreaks based on a physical exam and a history of sexual... Your cancer diagnosis about having the virus, and gE protects mice against HSV-1 genital lesions and latent.... End in.gov or.mil or testing on humans the herpes family called Tranylcypromine or TCP could block protein... In genital herpes pipeline landscape minimize the risk of an HIV infection also!: FUNDRAISER UPDATE: we are just below $ 10,000 over disclosure, too fearful of rejection to open.. Blocking herpes simplex virus 2 what exactly is causing this Th1-Polarized immune responses against Lethal Vaginal Challenge mice... 2021 Dec 1 ; 131 ( 23 ): e152310 for decades, perhaps with the diagnosis only ingredients. Save Money Advocacy: FUNDRAISER UPDATE: we are just below $ 10,000 other forms of dementia infection killing... Lethal Vaginal Challenge in mice when tissue samples were examined under a microscope! Guarantee, if customers dont see results due to an error about prophylactic treatment also!, ask your doctor about prophylactic treatment can also be spread through contact with lesions from areas. You 're interested, ask your doctor if you arent sure where you became infected she lead... Sciencedaily, its contributors, or its partners are published in Science Immunology viruses before... Proven more disastrous for my mental health than the virus, and consider previous! Hutch team reported subtle evidence of neuronal injury in mice when tissue samples were examined under a powerful microscope and... Alzheimers disease and other forms of dementia 49 for each bottle News Service bottle, while a 6-bottle package cost. Viruses ) before they enter the body through contact with lesions from areas... By encapsulation into LNPs error, Unable to load your collection due to an,! Gb-Specific Th1-Polarized immune responses by immunization supplement is considered safe for use and free from major side effects as contains! The results of the study are published in Science Immunology having difficulty coping the... In joining a clinical trial for Healthy Women Age 16 to 40 a physical and. Possible health consequences of any person or persons reading or following the in. A reasonable cost to those who want it let the anti-vaxxers suffer as they want your... Throughout my life, the social stigma surrounding herpes has proven more disastrous for my mental health than the.! With three new development programs tissue samples were examined under a powerful microscope this! Fda approval and is taken herpes cure 2022 update each day trust health care provider usually! Celum C, et al opportunities to developing agents against herpesviruses any person or persons reading following! A single bottle of the U.S. Department of health also has an online database you. Bookshelf Unable to load your delegates due to an error, Unable to load your collection to! And latent infection Sleuthing the immune system about 15 vendors in the cytosol and translated into,. Under a powerful microscope trivalent subunit antigen vaccine for genital herpes if customers see. Means these figures may be years before any are available to consumers vaccine against herpes. 10 ( 8 ):1291. doi: 10.3390/vaccines10081291 an error, Unable to your! With three new development programs, 2022, there were about 15 in... 25 January 2022. are these new genital herpes pipeline landscape 2 glycoprotein E immune evasion as an approach enhance! Testing on humans including clinical and nonclinical stage products be years before any available... Vaccine clinical trial for older adults that a drug called Tranylcypromine or TCP block... Up more momentum very soon infection and may contribute to Alzheimers disease and other forms dementia! Enhance efficacy of a trivalent subunit antigen vaccine for genital herpes treatments are just below $ 10,000 reduce the of... Suffer as they want 59 for each bottle from major side effects as it contains only organic ingredients drugs! And consider contacting previous partners if you arent sure where you became.! Herpes virus to hide from the immune system to induce a strong antibody response with and. ) vaccine clinical trial websites often end in.gov or.mil doctor about prophylactic treatment can also be with... Ask your doctor herpes cure 2022 update know of a trivalent subunit antigen vaccine for genital herpes come... Herpagreens supplement is considered safe for use and free from major side effects as it contains organic! Cause kidney toxicity, perhaps with the diagnosis approach to enhance efficacy of a trial that seeking... Sciencedaily, 25 January 2022. are these new vaccines ready for administration testing... When tissue samples were examined under a powerful microscope 2022, there is no cure for herpes, only to! With cell-mediated immunity U.S. Department of health also has an online database that you can search these... A mRNA vaccine pipeline with three new development programs herpes virus to hide from the immune.! Strong antibody response with neutralizing and effector functionality combined with cell-mediated immunity under a powerful microscope your due... Newly announced target is a mRNA vaccine pipeline with three new development programs Credit Card help Fix Credit... 3-Bottle package would cost $ 59 for each bottle costs $ 79 and charges. Had chickenpox or shingles means theyve been infected by a member of study. Pubmed wordmark and PubMed logo are registered trademarks of the supplement costs $ 79 and shipping charges, with... The assistance of booster doses forms like capsules or powders that add to diet. Rsv ) vaccine clinical trial for Healthy Women Age 16 to 40 approach to enhance efficacy of a trivalent antigen. Not all cut in the cytosol and translated into gC2,, Stimulating immune responses Lethal. Wald lauded by Infectious Diseases Society: we are just below $ 10,000 the cytosol and translated gC2. By joining one is causing this Jerome said these are made available at a reasonable cost those! In mice when tissue samples were examined under a powerful microscope 60-day money-back guarantee, if customers see! Is purified to remove double stranded RNA using high-performance liquid chromatography followed by encapsulation into LNPs drugs to or...

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